Embedded Files
2026
Choi DJ, Wu LJ. A Functional Atlas of Transcription Factor-Driven Astrocyte States In Vivo. Neurosci Bull. 2026 Aug 14;. doi: 10.1007/s12264-026-01703-5. [Epub ahead of print] PubMed PMID: 42599660. (First and Co-corresponding author)
Choi DJ, Ko Y, He P, Song EC, Choi JM, Curry RN, Lozzi B, Zheng YC, Lu K, Khatri L, Rao G, Deneen B. Glyoxalase 1 promotes glioma progression by modulating Sox2 transcriptional networks in glioma stem-like cells. Neuro Oncol. 2026 Jul 1;28(7):1680-1693. doi: 10.1093/neuonc/noag090. PubMed PMID: 42011505; PubMed Central PMCID: PMC13338327. (First and Co-corresponding author)
Choi DJ, Ko Y, He P, Song EC, Choi JM, Curry RN, Lozzi B, Zheng YC, Lu K, Khatri L, Rao G, Deneen B. Glyoxalase 1 promotes glioma progression by modulating Sox2 transcriptional networks in glioma stem-like cells. Neuro Oncol. 2026 Jul 1;28(7):1680-1693. doi: 10.1093/neuonc/noag090. PubMed PMID: 42011505; PubMed Central PMCID: PMC13338327. (First and Co-corresponding author)
Lozzi B, Gatesman TA, Dasgupta P, Sardar D, Ko Y, Mao C, Chen HC, Curry RN, Choi D, Mohila CA, Bondy ML, Rao G, Gallo M, Agnihotri S, Deneen B. Hp1bp3 loss links chromatin reorganization to metabolic vulnerability in glioma. Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2601061123. doi: 10.1073/pnas.2601061123. Epub 2026 Jun 10. PubMed PMID: 42268888; PubMed Central PMCID: PMC13273316.
2025
Choi DJ, Murali S, Kwon W, Woo J, Song EC, Ko Y, Sardar D, Lozzi B, Cheng YT, Williamson MR, Huang TW, Sanchez K, Jankowsky J, Deneen B. Astrocytic Sox9 overexpression in Alzheimer's disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function. Nat Neurosci. 2026 Jan;29(1):88-99. doi: 10.1038/s41593-025-02115-w. Epub 2025 Nov 21. PubMed PMID: 41272323; PubMed Central PMCID: PMC13159067.
Choi DJ, Murali S, Kwon W, Woo J, Song EC, Ko Y, Sardar D, Lozzi B, Cheng YT, Williamson MR, Huang TW, Sanchez K, Jankowsky J, Deneen B. Astrocytic Sox9 overexpression in Alzheimer's disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function. Nat Neurosci. 2026 Jan;29(1):88-99. doi: 10.1038/s41593-025-02115-w. Epub 2025 Nov 21. PubMed PMID: 41272323; PubMed Central PMCID: PMC13159067.
Curry RN, McDonald MF, He P, Lozzi B, Ko Y, O'Reilly I, Rosenbaum A, Kwon W, Fahim L, Marcus J, Powell N, Wang S, Ma J, Multani A, Choi DJ, Sardar D, Mohila C, Lee J, Gallo M, Harmanci A, Harmanci AS, Deneen B, Rao G. Mutant IDH impairs chromatin binding by PDGFB to promote chromosome instability. bioRxiv. 2025 Feb 25;. doi: 10.1101/2025.02.20.639365. PubMed PMID: 40060572; PubMed Central PMCID: PMC11888161.
2024
2024
Chen HC, He P, McDonald M, Williamson MR, Varadharajan S, Lozzi B, Woo J, Choi DJ, Sardar D, Huang-Hobbs E, Sun H, Ippagunta SM, Jain A, Rao G, Merchant TE, Ellison DW, Noebels JL, Bertrand KC, Mack SC, Deneen B. Histone serotonylation regulates ependymoma tumorigenesis. Nature. 2024 Aug;632(8026):903-910. doi: 10.1038/s41586-024-07751-z. Epub 2024 Jul 31. PubMed PMID: 39085609; PubMed Central PMCID: PMC11951423.
Chen HC, He P, McDonald M, Williamson MR, Varadharajan S, Lozzi B, Woo J, Choi DJ, Sardar D, Huang-Hobbs E, Sun H, Ippagunta SM, Jain A, Rao G, Merchant TE, Ellison DW, Noebels JL, Bertrand KC, Mack SC, Deneen B. Histone serotonylation regulates ependymoma tumorigenesis. Nature. 2024 Aug;632(8026):903-910. doi: 10.1038/s41586-024-07751-z. Epub 2024 Jul 31. PubMed PMID: 39085609; PubMed Central PMCID: PMC11951423.
Kwon W#, Choi DJ#, Yu K, Williamson MR, Murali S, Ko Y, Woo J, Deneen B. Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions. Int J Mol Sci. 2024 Jan 13;25(2). doi: 10.3390/ijms25021021. PubMed PMID: 38256095; PubMed Central PMCID: PMC10816327. (Co-First)
2023
2023
Huang-Hobbs E, Cheng YT, Ko Y, Luna-Figueroa E, Lozzi B, Taylor KR, McDonald M, He P, Chen HC, Yang Y, Maleki E, Lee ZF, Murali S, Williamson MR, Choi D, Curry R, Bayley J, Woo J, Jalali A, Monje M, Noebels JL, Harmanci AS, Rao G, Deneen B. Remote neuronal activity drives glioma progression through SEMA4F. Nature. 2023 Jul;619(7971):844-850. doi: 10.1038/s41586-023-06267-2. Epub 2023 Jun 28. PubMed PMID: 37380778; PubMed Central PMCID: PMC10840127
Huang-Hobbs E, Cheng YT, Ko Y, Luna-Figueroa E, Lozzi B, Taylor KR, McDonald M, He P, Chen HC, Yang Y, Maleki E, Lee ZF, Murali S, Williamson MR, Choi D, Curry R, Bayley J, Woo J, Jalali A, Monje M, Noebels JL, Harmanci AS, Rao G, Deneen B. Remote neuronal activity drives glioma progression through SEMA4F. Nature. 2023 Jul;619(7971):844-850. doi: 10.1038/s41586-023-06267-2. Epub 2023 Jun 28. PubMed PMID: 37380778; PubMed Central PMCID: PMC10840127
Sardar D, Cheng YT, Woo J, Choi DJ, Lee ZF, Kwon W, Chen HC, Lozzi B, Cervantes A, Rajendran K, Huang TW, Jain A, Arenkiel BR, Maze I, Deneen B. Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation. Science. 2023 Jun 16;380(6650):eade0027. doi: 10.1126/science.ade0027. Epub 2023 Jun 16. PubMed PMID: 37319217; PubMed Central PMCID: PMC10874521.
Sardar D, Cheng YT, Woo J, Choi DJ, Lee ZF, Kwon W, Chen HC, Lozzi B, Cervantes A, Rajendran K, Huang TW, Jain A, Arenkiel BR, Maze I, Deneen B. Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation. Science. 2023 Jun 16;380(6650):eade0027. doi: 10.1126/science.ade0027. Epub 2023 Jun 16. PubMed PMID: 37319217; PubMed Central PMCID: PMC10874521.
Choi DJ, Armstrong G, Lozzi B, Vijayaraghavan P, Plon SE, Wong TC, Boerwinkle E, Muzny DM, Chen HC, Gibbs RA, Ostrom QT, Melin B, Deneen B, Bondy ML, Gliogene Consortium, Genomics England Research Consortium, Bainbridge MN, The genomic landscape of familial glioma. Sci Adv. 2023 Apr 28;9(17):eade2675. doi: 10.1126/sciadv.ade2675. Epub 2023 Apr 28. PubMed PMID: 37115922; PubMed Central PMCID: PMC10146888.
Choi DJ, Armstrong G, Lozzi B, Vijayaraghavan P, Plon SE, Wong TC, Boerwinkle E, Muzny DM, Chen HC, Gibbs RA, Ostrom QT, Melin B, Deneen B, Bondy ML, Gliogene Consortium, Genomics England Research Consortium, Bainbridge MN, The genomic landscape of familial glioma. Sci Adv. 2023 Apr 28;9(17):eade2675. doi: 10.1126/sciadv.ade2675. Epub 2023 Apr 28. PubMed PMID: 37115922; PubMed Central PMCID: PMC10146888.
2021
2021
Kwon JK, Choi DJ, Yang H, Ko DW, Jou I, Park SM, Joe EH. Kir4.1 is coexpressed with stemness markers in activated astrocytes in the injured brain and a Kir4.1 inhibitor BaCl(2) negatively regulates neurosphere formation in culture. Korean J Physiol Pharmacol. 2021 Nov 1;25(6):565-574. doi: 10.4196/kjpp.2021.25.6.565. PubMed PMID: 34697267; PubMed Central PMCID: PMC8552822.
Kwon JK, Choi DJ, Yang H, Ko DW, Jou I, Park SM, Joe EH. Kir4.1 is coexpressed with stemness markers in activated astrocytes in the injured brain and a Kir4.1 inhibitor BaCl(2) negatively regulates neurosphere formation in culture. Korean J Physiol Pharmacol. 2021 Nov 1;25(6):565-574. doi: 10.4196/kjpp.2021.25.6.565. PubMed PMID: 34697267; PubMed Central PMCID: PMC8552822.
2020
2020
Choi DJ, Yang H, Gaire S, Lee KA, An J, Kim BG, Jou I, Park SM, Joe EH. Critical roles of astrocytic-CCL2-dependent monocyte infiltration in a DJ-1 knockout mouse model of delayed brain repair. Glia. 2020 Oct;68(10):2086-2101. doi: 10.1002/glia.23828. Epub 2020 Mar 16. PubMed PMID: 32176388. (First and Co-corresponding author)
Choi DJ, Yang H, Gaire S, Lee KA, An J, Kim BG, Jou I, Park SM, Joe EH. Critical roles of astrocytic-CCL2-dependent monocyte infiltration in a DJ-1 knockout mouse model of delayed brain repair. Glia. 2020 Oct;68(10):2086-2101. doi: 10.1002/glia.23828. Epub 2020 Mar 16. PubMed PMID: 32176388. (First and Co-corresponding author)
2019
2019
Cui Y, Jin X, Choi DJ, Choi JY, Kim HS, Hwang DH, Kim BG. Axonal degeneration in an in vitro model of ischemic white matter injury. Neurobiol Dis. 2020 Feb;134:104672. doi: 10.1016/j.nbd.2019.104672. Epub 2019 Nov 7. PubMed PMID: 31707117.
Cui Y, Jin X, Choi DJ, Choi JY, Kim HS, Hwang DH, Kim BG. Axonal degeneration in an in vitro model of ischemic white matter injury. Neurobiol Dis. 2020 Feb;134:104672. doi: 10.1016/j.nbd.2019.104672. Epub 2019 Nov 7. PubMed PMID: 31707117.
Choi DJ, An J, Jou I, Park SM, Joe EH. A Parkinson's disease gene, DJ-1, regulates anti-inflammatory roles of astrocytes through prostaglandin D(2) synthase expression. Neurobiol Dis. 2019 Jul;127:482-491. doi: 10.1016/j.nbd.2019.04.003. Epub 2019 Apr 4. PubMed PMID: 30954702. (First and Co-corresponding author)
Choi DJ, An J, Jou I, Park SM, Joe EH. A Parkinson's disease gene, DJ-1, regulates anti-inflammatory roles of astrocytes through prostaglandin D(2) synthase expression. Neurobiol Dis. 2019 Jul;127:482-491. doi: 10.1016/j.nbd.2019.04.003. Epub 2019 Apr 4. PubMed PMID: 30954702. (First and Co-corresponding author)
2018
2018
Choi DJ, Kwon JK, Joe EH. A Parkinson's disease gene, DJ-1, regulates astrogliosis through STAT3. Neurosci Lett. 2018 Oct 15;685:144-149. doi: 10.1016/j.neulet.2018.08.025. Epub 2018 Aug 29. PubMed PMID: 30171910.
Choi DJ, Kwon JK, Joe EH. A Parkinson's disease gene, DJ-1, regulates astrogliosis through STAT3. Neurosci Lett. 2018 Oct 15;685:144-149. doi: 10.1016/j.neulet.2018.08.025. Epub 2018 Aug 29. PubMed PMID: 30171910.
Joe EH, Choi DJ, An J, Eun JH, Jou I, Park S. Astrocytes, Microglia, and Parkinson's Disease. Exp Neurobiol. 2018 Apr;27(2):77-87. doi: 10.5607/en.2018.27.2.77. Epub 2018 Apr 24. Review. PubMed PMID: 29731673; PubMed Central PMCID: PMC5934545.
Nam D, Kim H, Choi DJ, Bae YH, Lee BD, Son I, Seol W. Characterization of Parkinson's disease-related pathogenic TMEM230 mutants. Anim Cells Syst (Seoul). 2018;22(2):140-147. doi: 10.1080/19768354.2018.1453545. eCollection 2018. PubMed PMID: 30460091; PubMed Central PMCID: PMC6138308.
Kyung JW, Kim JM, Lee W, Ha TY, Cha SH, Chung KH, Choi DJ, Jou I, Song WK, Joe EH, Kim SH, Park SM. DJ-1 deficiency impairs synaptic vesicle endocytosis and reavailability at nerve terminals. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1629-1634. doi: 10.1073/pnas.1708754115. Epub 2018 Jan 31. PubMed PMID: 29386384; PubMed Central PMCID: PMC5816138.
2017
Choi DJ, Eun JH, Kim BG, Jou I, Park SM, Joe EH. A Parkinson's disease gene, DJ-1, repairs brain injury through Sox9 stabilization and astrogliosis. Glia. 2018 Feb;66(2):445-458. doi: 10.1002/glia.23258. Epub 2017 Nov 6. PubMed PMID: 29105838.
2012-2016
Choi I, Choi DJ, Yang H, Woo JH, Chang MY, Kim JY, Sun W, Park SM, Jou I, Lee SH, Joe EH. PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes. Mol Brain. 2016 Jan 8;9:5. doi: 10.1186/s13041-016-0186-6. PubMed PMID: 26746235; PubMed Central PMCID: PMC4706723.
Jeong HK, Ji KM, Min KJ, Choi I, Choi DJ, Jou I, Joe EH. Astrogliosis is a possible player in preventing delayed neuronal death. Mol Cells. 2014 Apr;37(4):345-55. doi: 10.14348/molcells.2014.0046. Epub 2014 Apr 22. PubMed PMID: 24802057; PubMed Central PMCID: PMC4012084.
Kim JH, Choi DJ, Jeong HK, Kim J, Kim DW, Choi SY, Park SM, Suh YH, Jou I, Joe EH. DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: A novel anti-inflammatory function of DJ-1. Neurobiol Dis. 2013 Dec;60:1-10. doi: 10.1016/j.nbd.2013.08.007. Epub 2013 Aug 20. PubMed PMID: 23969237.
Bae SK#, Heo CH#, Choi DJ#, Sen D, Joe EH, Cho BR, Kim HM. A ratiometric two-photon fluorescent probe reveals reduction in mitochondrial H2S production in Parkinson's disease gene knockout astrocytes. J Am Chem Soc. 2013 Jul 3;135(26):9915-23. doi: 10.1021/ja404004v. Epub 2013 Jun 18. PubMed PMID: 23745510. (Co-First)
Kim B, Yang MS, Choi D, Kim JH, Kim HS, Seol W, Choi S, Jou I, Kim EY, Joe EH. Impaired inflammatory responses in murine Lrrk2-knockdown brain microglia. PLoS One. 2012;7(4):e34693. doi: 10.1371/journal.pone.0034693. Epub 2012 Apr 9. PubMed PMID: 22496842; PubMed Central PMCID: PMC3322140.
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